Home » Trials » SLCTR/2007/010


A controlled trial to compare the diuretic action of frusemide with the Ayurvedic diuretic medicinal preparations Gokshura guggulu, Chandraprabhavatin and Vajrakshara -

SLCTR Registration Number

SLCTR/2007/010


Date of Registration

21 Sep 2007

The date of last modification

Nov 21, 2017


Trial Status



Application Summary


Scientific Title of Trial

A controlled trial to compare the diuretic action of frusemide with the Ayurvedic diuretic medicinal preparations Gokshura guggulu, Chandraprabhavatin and Vajrakshara


Public Title of Trial

Comparison of diuretic actions of frusemide with Ayurvedic diuretics


Disease of Health Condition(s) Studied

Patients requiring diuretic therapy


Scientific Acronym

None


Public Acronym

None


Brief title

None


Universal Trial Number

None


Any other number(s) assigned to the trial and issuing authority

ERC/07-018 (Ethics Review Committee of the Sri Lanka Medical Association)


Trial Details


What is the research question being addressed?

Are Ayurvedic diuretic medicines safe and effective?


Type of study

Interventional


Study design

Allocation

Randomized controlled trial


Masking

Single blinded


Control

Active


Assignment

Parallel


Purpose


Purpose


Intervention(s) planned

Giving frusemide 40 mg orally and one of the three Ayurvedic preparations and assessing diuretic action by measuring urine flow rate, K+, Na+ and osmolar clearance


Inclusion criteria

Patients requiring diuretic therapy, but not seriously ill, giving voluntary informed consent


Exclusion criteria

Patients seriously ill



Primary outcome(s)

Effective diuresis


Primary outcome(s) - Time of assessment(s)


Secondary outcome

Adverse effects, patient preference


Secondary outcome(s) - Time of assessment(s)



Target number/sample size

100 patients (approx)


Countries of recruitment

Sri Lanka


Anticipated start date


Anticipated end date

2009-12-12


Recruitment status

Complete


State of ethics review approval

Approved by the Ethics Review Committee of the Sri Lanka Medical Association (ERC/07-018)


Funding source

National Science Foundation, Sri Lanka



Contact & Sponsor Information


Contact person for Scientific Queries/Principal Investigator

Colvin Goonaratna
Professor
Faculty of Medicine Kynsey Road Colombo 8
4612643
0773-488289
4612643
colvin_cg@yahoo.com

Contact Person for Public Queries

Colvin Goonaratna
Professor
Faculty of Medicine Kynsey Road Colombo 8
4612643
0773-488289
4612643
colvin_cg@yahoo.com


Primary study sponsor/organization

Faculty of Medicine, Colombo

Kynsey Road Colombo 8
4612643
4612643

Secondary study sponsor (If any)

None