Date Modified

2021-04-21

Period

48/months

Report Summary

• Trial commenced on 10.10.2016. • Recruitment status: recruitment complete: follow up complete. • Number assessed for eligibility: 250 • Number recruited and allocated/randomized: 225 • Final sample size: Only 173 patients remained until the end of the study (Aerobic -58, combined -55, control- 60) • Trial completed on 31.01.2021. Only 194 patients completed the 3 months follow up (Aerobic -67, combined -64, control- 63) and only 173 patients remained until the end of the study at 6 months (Aerobic -58, combined -55, control- 60). Suprathreshold intensity ratings for sucrose at 3 and 6 months- aerobic/combined/control group At 3 months, the aerobic group (p=0.02) and the combined group (p=0.022) showed a significantly higher rating for the highest concentration of sucrose (2.02M) studied showed compared to controls. At 6 months, the aerobic group (2.02M, p=0.022, 0.64M, p=0.003) and the combined group (2.02M, p=0.011, 0.64M, p=0.011) showed significantly higher ratings for the 2.02M and 0.64M sucrose solutions compared to the control group. Preference for sucrose at 3 and 6 months- aerobic/combined/control group At 3 months, preference for sucrose in the aerobic and combined exercise groups showed no significant change but were significantly reduced at 6 months compared to control group (aerobic p= 0.044, combined p=0.002). Hunger-satiety at 3 and 6 months- aerobic/combined/control group At both 3 and 6 months, the ratings of hunger in the aerobic group were significantly reduced at -30 and +30 minutes (p<0.05), while the satiety was significantly increased only at -30 minutes (p<0.05) compared to the control group. At 3 months in the combined exercise group, hunger was reduced at -30 minutes and at 6 months the reduction was significant at -30 and +30 minutes (p<0.05). The satiety level significantly increased at -30 minutes at 3 months and significantly increased at -30, +30 and +60 minutes at 6 months compared to controls (p<0.05) Total calory and macronutrient consumption At 3 and 6 months, compared to the controls the aerobic exercise group and the combined exercise group showed significant reduction in total calory and carbohydrate intake (p<0.05) and increased levels of protein and fat consumption which was not significant. Glycaemic control Both exercise groups showed significant reduction in HbA1c % following 6 months exercises compared to controls (p<0.05).

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